Jalyn

Generic Name: dutasteride and tamsulosin (doo TAS ter ide and tam soo LOE sin)

Brand Names: Jalyn

What is dutasteride and tamsulosin?

Dutasteride prevents the conversion of testosterone to dihydrotestosterone (DHT) in the body. DHT is involved in the development of benign prostatic hyperplasia (BPH).

Tamsulosin is in a group of drugs called alpha-adrenergic (AL-fa ad-ren-ER-jik) blockers. Tamsulosin relaxes the muscles in the prostate and bladder neck, making it easier to urinate.

The combination of dutasteride and tamsulosin is used to treat benign prostatic hyperplasia (BPH) in men with an enlarged prostate.

Dutasteride and tamsulosin may also be used for purposes not listed in this medication guide.

What is the most important information I should know about dutasteride and tamsulosin?

You should not use this medication if you are allergic to dutasteride (Avodart) or tamsulosin (Flomax). Do not take dutasteride and tamsulosin if you are also taking alfuzosin (Uroxatral), doxazosin (Cardura), prazosin (Minipress), silodosin (Rapaflo), tamsulosin (Flomax), or terazosin (Hytrin). Dutasteride and tamsulosin should never be taken by a woman, a child, or a teenager. Dutasteride can be absorbed through the skin, and women or children should not be permitted to handle dutasteride and tamsulosin capsules. This medication can cause birth defects if a woman is exposed to it during pregnancy. Dutasteride and tamsulosin capsules should not be handled by a woman who is pregnant or who may become pregnant. If a woman accidentally comes into contact with this medication from a leaking capsule, wash the area with soap and water right away. Do not donate blood while taking this medication and for at least 6 months after your treatment ends. Dutasteride can be carried in the blood and could cause birth defects if a pregnant women receives a transfusion with blood that contains dutasteride. Using dutasteride and tamsulosin may increase your risk of developing prostate cancer. Your doctor will perform tests to make sure you do not have other conditions that would prevent you from safely using dutasteride and tamsulosin.

Tamsulosin can affect your pupils during cataract surgery. Tell your eye surgeon ahead of time that you are using this medication. Do not stop using dutasteride and tamsulosin before surgery unless your surgeon tells you to.

There are many other drugs that can interact with dutasteride and tamsulosin. Tell your doctor about all medications you use.

What should I discuss with my healthcare provider before taking dutasteride and tamsulosin?

You should not use this medication if you are allergic to dutasteride (Avodart) or tamsulosin (Flomax). Do not take dutasteride and tamsulosin if you are also taking alfuzosin (Uroxatral), doxazosin (Cardura), prazosin (Minipress), silodosin (Rapaflo), tamsulosin (Flomax), or terazosin (Hytrin). Dutasteride and tamsulosin should never be taken by a woman, a child, or a teenager. Dutasteride can be absorbed through the skin, and women or children should not be permitted to handle dutasteride and tamsulosin capsules.

To make sure you can safely take this medication, tell your doctor if you have any of these other conditions:

• 
  

  low blood pressure;

  
  


• 
  

  high blood pressure (hypertension);

  
  


• 
  

  liver disease;

  
  


• 
  

  severe kidney disease;

  
  


• 
  

  a history of prostate cancer; or

  
  


• 
  

  if you are allergic to sulfa drugs or to finasteride (Propecia, Proscar).

  
  

Using dutasteride and tamsulosin may increase your risk of developing prostate cancer. Your doctor will perform tests to make sure you do not have other conditions that would prevent you from safely using dutasteride and tamsulosin. Although dutasteride and tamsulosin is not for use by women, this medication can cause birth defects if a woman is exposed to it during pregnancy. Dutasteride and tamsulosin capsules should not be handled by a woman who is pregnant or who may become pregnant. If a woman accidentally comes into contact with this medication from a leaking capsule, wash the area with soap and water right away.

Tamsulosin can affect your pupils during cataract surgery. Tell your eye surgeon ahead of time that you are using this medication. Do not stop using dutasteride and tamsulosin before surgery unless your surgeon tells you to.

How should I take dutasteride and tamsulosin?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Dutasteride and tamsulosin is usually taken once a day, approximately 30 minutes after a meal. Try to take this medication at the same time each day. Do not crush, chew, or open a dutasteride and tamsulosin capsule. Swallow it whole. A broken or leaking dutasteride and tamsulosin capsule can irritate your lips, mouth, or throat. Tamsulosin lowers blood pressure and may cause dizziness or fainting, especially when you first start taking dutasteride and tamsulosin. Call your doctor if you have severe dizziness or feel like you might pass out. It may take up to 6 months before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve.

To be sure this medication is helping your condition and not causing harmful effects, your blood may need to be tested often. Your doctor will also test your prostate specific antigen (PSA) to check for prostate cancer. Visit your doctor regularly.

Store at room temperature away from moisture and heat. Do not use a capsule that has been exposed to high heat, which can cause the capsule to change shape or color.

See also: Jalyn dosage (in more detail)

What happens if I miss a dose?

Take the missed dose 30 minutes after your next meal. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

If you miss your doses for several days in a row, contact your doctor before restarting the medication. You may need a lower dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include extreme dizziness or fainting.

What should I avoid while taking dutasteride and tamsulosin?

Do not donate blood while taking this medication and for at least 6 months after your treatment ends. Dutasteride can be carried in the blood and could cause birth defects if a pregnant women receives a transfusion with blood that contains dutasteride. Dutasteride and tamsulosin may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Dutasteride and tamsulosin side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop taking this medication and call your doctor at once if you have a serious side effect such as:

• 
  

  feeling like you might pass out; or

  
  


• 
  

  penis erection that is painful or lasts 4 hours or longer.

  
  

Less serious side effects may include:

• 
  

  decreased libido (sex drive);

  
  


• 
  

  decreased amount of semen released during sex;

  
  


• 
  

  impotence (trouble getting or keeping an erection);

  
  


• 
  

  breast tenderness or enlargement;

  
  


• 
  

  mild dizziness; or

  
  


• 
  

  runny nose.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect dutasteride and tamsulosin?

Tell your doctor about all other medications you use, especially:

• 
  

  cimetidine (Tagamet);

  
  


• 
  

  conivaptan (Vaprisol);

  
  


• 
  

  cyclosporine (Gengraf, Neoral, Sandimmune);

  
  


• 
  

  imatinib (Gleevec);

  
  


• 
  

  isoniazid (for treating tuberculosis);

  
  


• 
  

  methimazole (Tapazole);

  
  


• 
  

  pioglitazone (Actos);

  
  


• 
  

  ropinirole (Requip);

  
  


• 
  

  ticlopidine (Ticlid);

  
  


• 
  

  a blood thinner such as warfarin (Coumadin, Jantoven);

  
  


• 
  

  an antibiotic such as clarithromycin (Biaxin), doxycycline (Adoxa, Alodox, Avidoxy, Oraxyl, Doryx, Oracea, Vibramycin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole), metronidazole (Flagyl, Protostat), telithromycin (Ketek), terbinafine (Lamisil), or tetracycline (Ala-Tet, Brodspec, Panmycin, Sumycin, Tetracap);

  
  


• 
  

  an antidepressant such as clomipramine (Anafranil), desipramine (Norpramin), duloxetine (Cymbalta), fluoxetine (Prozac, Sarafem), nefazodone, paroxetine (Paxil), sertraline (Zoloft), tranylcypromine (Parnate), or trazodone (Desyrel, Oleptro);

  
  


• 
  

  antifungal medication such as fluconazole (Diflucan), itraconazole (Sporanox), ketoconazole (Nizoral), miconazole (Oravig), or voriconazole (Vfend);

  
  


• 
  

  anti-malaria medication such as chloroquine (Arelan) or pyrimethamine (Daraprim), or quinine (Qualaquin);

  
  


• 
  

  erectile dysfunction medicine such as sildenafil (Viagra), tadalafil (Cialis), or vardenafil (Levitra);

  
  


• 
  

  heart or blood pressure medication such as amiodarone (Cordarone, Pacerone), nicardipine (Cardene), or quinidine (Quin-G), and others;

  
  


• 
  

  HIV/AIDS medicine such as atazanavir (Reyataz), delavirdine (Rescriptor), efavirenz (Sustiva), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), saquinavir (Invirase), or ritonavir (Norvir); or

  
  


• 
  

  medicine to treat psychiatric disorders, such as aripiprazole (Abilify), chlorpromazine (Thorazine), clozapine (Clozaril, FazaClo), fluphenazine (Permitil, Prolixin), haloperidol (Haldol), perphenazine (Trilafon), or thioridazine (Mellaril).

  
  

This list is not complete and there are many other drugs that can interact with dutasteride and tamsulosin. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.

More Jalyn resources

• Jalyn Side Effects (in more detail)
• Jalyn Dosage
• Jalyn Use in Pregnancy & Breastfeeding
• Jalyn Drug Interactions
• Jalyn Support Group
• 11 Reviews for Jalyn - Add your own review/rating

• Jalyn Prescribing Information (FDA)


• Jalyn Advanced Consumer (Micromedex) - Includes Dosage Information


• Jalyn MedFacts Consumer Leaflet (Wolters Kluwer)


• Jalyn Consumer Overview

Compare Jalyn with other medications

• Benign Prostatic Hyperplasia

Where can I get more information?

• Your pharmacist can provide more information about dutasteride and tamsulosin.

See also: Jalyn side effects (in more detail)

fluoride

Generic Name: fluoride (FLOR ide)

Brand names: Altaflor, Ethedent Chewable, Fluor-A-Day, Fluoritab, Flura-Drops, Flura-Loz, Flura-Tab, Karidium, Lozi-Flur, Luride, Nafrinse, Pharmaflur, Pharmaflur 1.1, ...show all 19 brand names.Pediaflor Drops, Luride-SF, Fluorabon, Fluorodex, Renaf, EPIFLUR

What is fluoride?

Fluoride is a substance that strengthens tooth enamel. This helps to prevent dental cavities.

Fluoride is used as a medication to prevent tooth decay in people that have a low level of fluoride in their drinking water. Fluoride is also used to prevent tooth decay in people who undergo radiation of the head and/or neck, which may cause dryness of the mouth and an increased incidence of tooth decay.

Fluoride may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about fluoride?

You should not use fluoride if the level of fluoride in your drinking water is greater than 0.7 parts per million (ppm).

Before using fluoride, tell your dentist and doctor if you are on a low salt or a salt free diet. You may not be able to use fluoride, or you may need special tests while you are using it.

Do not take fluoride with milk, other dairy products, or calcium supplements. Calcium can make it harder for your body to absorb fluoride.

Avoid using antacids without your doctor's advice. Use only the specific type of antacid your doctor recommends. Many antacids contain calcium, which can interfere with fluoride absorption.

What should I discuss with my healthcare provider before taking fluoride?

You should not use fluoride if the level of fluoride in your drinking water is greater than 0.7 parts per million (ppm).

Before using fluoride, tell your dentist and doctor if you are on a low salt or a salt free diet. You may not be able to use fluoride, or you may need special tests while you are using it.

Talk to your doctor and dentist before taking fluoride if you are pregnant or could become pregnant during treatment. Talk to your doctor and dentist before taking fluoride if you are breast-feeding. The American Dental Association's Council on Dental Therapeutics recommends the use of fluoride by children up to 13 years of age; the American Academy of Pediatrics recommends fluoride supplementation by children until the age of 16 years of age. Do not give a 1-mg tablet to a child younger than 3 years old, or when your drinking water fluoride content is equal to or greater than 0.3 ppm.

How should I take fluoride?

Use this medication exactly as directed on the label, or as prescribed by your doctor. Do not use it in larger amounts or for longer than recommended.

Take this medicine with a full glass of water. Do not take fluoride with milk or other dairy products. Calcium can make it harder for your body to absorb fluoride.

Suck on the fluoride lozenge until it dissolves completely in your mouth. Do not chew the lozenge or swallow it whole.

The chewable forms of fluoride can be chewed, swallowed, dissolved in the mouth, added to drinking water or fruit juice, or added to water for use in infant formula or other food.

The fluoride drops can be taken by mouth undiluted, or mixed with fluid or food.

If you mix fluoride with food or water, drink or eat this mixture right away. Do not save it for later use.

It is important to take fluoride regularly to get the most benefit.

Store fluoride at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include nausea, vomiting, stomach pain, diarrhea, drooling, numbness or tingling, loss of feeling anywhere in your body, muscle stiffness, or seizure (convulsions).

What should I avoid while taking fluoride?

Do not take fluoride with milk, other dairy products, or calcium supplements. Calcium can make it harder for your body to absorb fluoride.

Avoid using antacids without your doctor's advice. Use only the specific type of antacid your doctor recommends. Many antacids contain calcium, which can interfere with fluoride absorption.

Fluoride side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor if you have any of the following side effects:

• 
  

  discolored teeth;

  
  


• 
  

  weakened tooth enamel; or

  
  


• 
  

  any changes in the appearance of your teeth.

  
  

Less serious side effects may include:

• 
  

  stomach upset;

  
  


• 
  

  headache; or

  
  


• 
  

  weakness.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect fluoride?

There may be other drugs that can interact with fluoride. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

More fluoride resources

• Fluoride Use in Pregnancy & Breastfeeding
• Drug Images
• Fluoride Support Group
• 0 Reviews for Fluoride - Add your own review/rating

• Epiflur Prescribing Information (FDA)


• Fluor-A-Day Chewable Tablets MedFacts Consumer Leaflet (Wolters Kluwer)


• Fluor-A-Day Advanced Consumer (Micromedex) - Includes Dosage Information


• Fluor-a-Day Prescribing Information (FDA)


• Fluorides Monograph (AHFS DI)


• Fluoritab Drops MedFacts Consumer Leaflet (Wolters Kluwer)


• Lozi-Flur Lozenges MedFacts Consumer Leaflet (Wolters Kluwer)

Compare fluoride with other medications

• Prevention of Dental Caries

Where can I get more information?

• Your pharmacist can provide more information about fluoride.

Cromophta-Pos

Cromophta-Pos may be available in the countries listed below.

Ingredient matches for Cromophta-Pos

Cromoglicic Acid

Cromoglicic Acid disodium salt (a derivative of Cromoglicic Acid) is reported as an ingredient of Cromophta-Pos in the following countries:

• Belgium


• Luxembourg

International Drug Name Search

Captowa

Captowa may be available in the countries listed below.

Ingredient matches for Captowa

Captopril

Captopril is reported as an ingredient of Captowa in the following countries:

• Japan

International Drug Name Search

Protopam Chloride

Generic Name: pralidoxime (Injection route)

pral-i-DOX-eem

Commonly used brand name(s)

In the U.S.

• Protopam Chloride

Available Dosage Forms:

• Powder for Solution


• Injectable

Therapeutic Class: Nerve Gas Antidote

Uses For Protopam Chloride

Pralidoxime injection is used together with another medicine called atropine to treat poisoning caused by organic phosphorus pesticides (e.g., diazinon, malathion, mevinphos, parathion, and sarin) and by organophosphate chemicals (“nerve gases”) used in chemical warfare.

Pralidoxime injection is also used to treat overdose of medicines (e.g., ambenonium, neostigmine, pyridostigmine), that are used to treat myasthenia gravis. Poisoning with these chemicals or medicines causes your muscles, including the muscles that help you breathe, to become weak. Pralidoxime is used to help you get back strength in your muscles.

This medicine is to be given only by or under the direct supervision of a doctor or trained military personnel.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although this use is not included in product labeling, pralidoxime has been used in some patients to treat poisoning caused by certain carbamate pesticides.

Before Using Protopam Chloride

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of pralidoxime injection in children.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of pralidoxime injection in the elderly. However, elderly patients are more likely to have age-related kidney, liver, or heart problems, which may require caution and an adjustment in the dose for patients receiving pralidoxime injection.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Kidney disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

• Myasthenia gravis (severe muscle weakness)—Use with caution. May make this condition worse.

Proper Use of Protopam Chloride

A nurse or other trained health professional will give you this medicine in a hospital or clinic. You may also be taught how to give your medicine at home. This medicine is preferably given through a needle placed in one of your veins. It may also be given as a shot under your skin or into a muscle.

This medicine is available in two forms: a vial and an autoinjector.

For patients using the pralidoxime autoinjector (automatic injection device):

• You will be trained to use the pralidoxime autoinjector by a medic or other trained military personnel. You will also be told the conditions under which it should be used.


• The autoinjector also comes with patient directions. Read them carefully before you actually need to use this medicine. Then, when an emergency arises, you will know how to inject the pralidoxime.


• It is important that you do not remove the safety cap on the autoinjector until you are ready to use it. This prevents spillage of the medicine from the device during storage and handling.


• To use the pralidoxime autoinjector:
  
  • Remove the gray safety cap.
  
  
  • Place the black tip of the device on the thigh, with the injector pointed straight at the thigh.
  
  
  • Press hard into the thigh until the autoinjector functions. Hold in place for several seconds. Remove the autoinjector and dispose of it as directed.
  
  
  • Massage the injected area for 10 seconds.
  
  

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For injection dosage form:
  
  • For treatment of organic phosphorus pesticide poisoning:
    
    • Adults and teenagers—At first, 1000 to 2000 milligrams (mg) injected into a vein usually as an infusion in 100 milliliters (mL) of normal saline, over a 15- to 30-minute period. The dose may be repeated after one hour, and then every eight to twelve hours if muscle weakness persists.
    
    
    • Children and teenagers 16 years of age and younger—Dose is based on body weight and must be determined by your doctor. The dose is usually 20 to 50 milligrams (mg) per kilogram (kg) (9.07 to 22.7 mg per pound) of body weight injected into a vein. The dose may be repeated after one hour, and then every ten to twelve hours if muscle weakness persists.
    
    
  
  
  • For treatment of organic phosphorus chemical (“nerve gas”) poisoning:
    
    • Adults, teenagers, and children weighing 40 kilograms (kg) or more—600 milligrams (mg) or 2 milliliters (mL) injected into a muscle. The dose may be repeated fifteen minutes after the first dose and fifteen minutes after the second dose, if needed.
    
    
    • Children and teenagers 16 years of age and younger weighing less than 40 kilograms (kg)—Dose is based on body weight and must be determined by your doctor. The dose is 15 milligrams (mg) per kilogram (kg) of body weight injected into the muscles of the thighs. The dose may be repeated fifteen minutes after the first dose and fifteen minutes after the second dose, if needed.
    
    
  
  
  • For treatment of overdose of medicines used to treat myasthenia gravis:
    
    • Adults and teenagers—At first, 1000 to 2000 milligrams (mg) injected into a vein. Then, 250 mg is injected into a vein every five minutes.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Protopam Chloride

Your doctor will check your progress closely while you or your child are receiving this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it. Blood tests may be needed to check for unwanted effects.

Call your doctor right away if you or your child have fast heartbeat, difficulty or trouble with breathing, increased muscle weakness, or severe tiredness after receiving this medicine.

This medicine will add to the effects of CNS depressants (medicines that may make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates; medicine for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the above while you are using this medicine.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Protopam Chloride Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

• Blurred or double vision


• change in near or distance vision


• difficult or rapid breathing


• difficulty in focusing the eyes


• difficulty with speaking


• dizziness


• fast, pounding, or irregular heartbeat or pulse


• muscle stiffness or weakness


• pain at the injection site (after injection into a muscle)

Incidence not known

• Deep or fast breathing with dizziness


• numbness of the feet, hands, and around the mouth

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Drowsiness


• headache


• nausea

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Protopam Chloride side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Protopam Chloride resources

• Protopam Chloride Side Effects (in more detail)
• Protopam Chloride Use in Pregnancy & Breastfeeding
• Protopam Chloride Drug Interactions
• Protopam Chloride Support Group
• 0 Reviews for Protopam Chloride - Add your own review/rating

• Protopam Chloride Concise Consumer Information (Cerner Multum)


• Pralidoxime Chloride Monograph (AHFS DI)

Compare Protopam Chloride with other medications

• Anticholinesterase Overdose
• Nerve Agent Poisoning
• Organophosphate Poisoning

Cromosol

Cromosol may be available in the countries listed below.

Ingredient matches for Cromosol

Cromoglicic Acid

Cromoglicic Acid disodium salt (a derivative of Cromoglicic Acid) is reported as an ingredient of Cromosol in the following countries:

• Czech Republic


• Lithuania


• Poland


• Switzerland


• Tunisia

International Drug Name Search

Cronase

Cronase may be available in the countries listed below.

Ingredient matches for Cronase

Cromoglicic Acid

Cromoglicic Acid disodium salt (a derivative of Cromoglicic Acid) is reported as an ingredient of Cronase in the following countries:

• Israel

Loratadine

Loratadine is reported as an ingredient of Cronase in the following countries:

• Indonesia

Pseudoephedrine

Pseudoephedrine sulfate (a derivative of Pseudoephedrine) is reported as an ingredient of Cronase in the following countries:

• Indonesia

International Drug Name Search

Texacort

Generic Name: hydrocortisone (Topical application route)

hye-droe-KOR-ti-sone

Commonly used brand name(s)

In the U.S.

• Ala-Cort


• Ala-Scalp HP


• Anusol HC


• Aquanil HC


• Beta HC


• Caldecort


• Cetacort


• Corta-Cap


• Cortagel Extra Strength


• Cortaid


• CortAlo With Aloe


• Corticaine


• Corticool Maximum Strength


• Cortizone-10


• Cortizone-5


• Cotacort


• Delacort


• Dermarest


• Dermtex-HC


• Foille Cort


• Gly-Cort


• Hydrozone Plus


• Hytone


• Instacort-10


• Ivy Soothe


• IvyStat


• Keratol HC


• Kericort 10


• Lacticare-HC


• Locoid


• Locoid Lipocream


• Medi-Cortisone Maximum Strength


• Microcort


• Mycin Scalp


• Neutrogena T/Scalp


• NuCort


• Nupercainal HC


• Nutracort


• Pandel


• Pediaderm HC Kit


• Preparation H Hydrocortisone


• Proctocream-HC


• Recort Plus


• Sarnol-HC Maximum Strength


• Scalacort


• Scalpcort


• Summer's Eve Specialcare


• Texacort


• Therasoft Anti-Itch & Dermatitis


• U-Cort


• Westcort

In Canada

• Barriere-Hc


• Cortate


• Cort-Eze


• Cortoderm Mild Ointment


• Cortoderm Regular Ointment


• Emo-Cort


• Emo-Cort Scalp Solution


• Hydrocortisone Cream


• Novo-Hydrocort


• Novo-Hydrocort Cream


• Prevex Hc


• Sarna Hc

Available Dosage Forms:

• Solution


• Cream


• Spray


• Lotion


• Ointment


• Pad


• Liquid


• Gel/Jelly


• Kit


• Foam


• Stick


• Paste

Therapeutic Class: Corticosteroid, Weak

Pharmacologic Class: Adrenal Glucocorticoid

Uses For Texacort

Hydrocortisone topical is used to help relieve redness, itching, swelling, or other discomfort caused by skin conditions. This medicine is a corticosteroid (cortisone-like medicine or steroid).

This medicine is available both over-the-counter (OTC) and with your doctor's prescription.

Before Using Texacort

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of hydrocortisone topical in the pediatric population. However, because of this medicine's toxicity, it should be used with caution. Children may absorb large amounts through the skin, which can cause serious side effects. If your child is using this medicine, follow your doctor's instructions very carefully.

Geriatric

No information is available on the relationship of age to the effects of hydrocortisone topical in geriatric patients.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Cushing's syndrome (adrenal gland disorder) or


• Diabetes or


• Hyperglycemia (high blood sugar) or


• Intracranial hypertension (increased pressure in the head)—Use with caution. May make these conditions worse.

• Infection of the skin at or near the place of application or


• Large sores, broken skin, or severe skin injury at the place of application—The chance of side effects may be increased.

Proper Use of hydrocortisone

This section provides information on the proper use of a number of products that contain hydrocortisone. It may not be specific to Texacort. Please read with care.

It is very important that you use this medicine only as directed by your doctor. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. To do so may cause unwanted side effects or skin irritation.

This medicine is for use on the skin only. Do not get it in your eyes. Do not use it on skin areas that have cuts, scrapes, or burns. If it does get on these areas, rinse it off right away with water.

This medicine should only be used for skin conditions that your doctor is treating. Check with your doctor before using it for other conditions, especially if you think that a skin infection may be present. This medicine should not be used to treat certain kinds of skin infections or conditions, such as severe burns.

To use:

• Wash your hands with soap and water before and after using this medicine.


• Apply a thin layer of this medicine to the affected area of the skin. Rub it in gently.


• With the lotion, shake it well before using.


• Do not bandage or otherwise wrap the skin being treated unless directed to do so by your doctor.


• If the medicine is applied to the diaper area of an infant, do not use tight-fitting diapers or plastic pants unless directed to do so by your doctor.


• If your doctor ordered an occlusive dressing or airtight covering to be applied over the medicine, make sure you know how to apply it. Occlusive dressings increase the amount of medicine absorbed through your skin, so use them only as directed. If you have any questions about this, check with your doctor.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For redness, itching, and swelling of the skin:
  
  • For topical dosage form (cream):
    
    • Adults—Apply to the affected area of the skin two or three times per day.
    
    
    • Children—Apply to the affected area of the skin two or three times per day.
    
    
  
  
  • For topical dosage form (lotion):
    
    • Adults—Apply to the affected area of the skin two to four times per day.
    
    
    • Children—Apply to the affected area of the skin two to four times per day.
    
    
  
  
  • For topical dosage form (ointment):
    
    • Adults—Apply to the affected area of the skin three or four times per day.
    
    
    • Children—Apply to the affected area of the skin three or four times per day.
    
    
  
  
  • For topical dosage form (solution):
    
    • Adults—Apply to the affected area of the skin three or four times per day.
    
    
    • Children—Apply to the affected area of the skin three or four times per day.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Texacort

It is very important that your doctor check your or your child's progress at regular visits for any unwanted effects that may be caused by this medicine.

If your or your child's symptoms do not improve within a few days, or if they become worse, check with your doctor.

Using too much of this medicine or using it for a long time may increase your risk of having adrenal gland problems. The risk is greater for children and patients who use large amounts for a long time. Talk to your doctor right away if you or your child have more than one of these symptoms while you are using this medicine: blurred vision; dizziness or fainting; a fast, irregular, or pounding heartbeat; increased thirst or urination; irritability; or unusual tiredness or weakness.

Stop using this medicine and check with your doctor right away if you or your child have a skin rash, burning, stinging, swelling, or irritation on the skin.

Do not use cosmetics or other skin care products on the treated areas.

Texacort Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known

• Blistering, burning, crusting, dryness, or flaking of the skin


• irritation


• itching, scaling, severe redness, soreness, or swelling of the skin


• redness and scaling around the mouth


• thinning of the skin with easy bruising, especially when used on the face or where the skin folds together (e.g. between the fingers)


• thinning, weakness, or wasting away of the skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

• Acne or pimples


• burning and itching of the skin with pinhead-sized red blisters


• burning, itching, and pain in hairy areas, or pus at the root of the hair


• increased hair growth on the forehead, back, arms, and legs


• lightening of normal skin color


• lightening of treated areas of dark skin


• reddish purple lines on the arms, face, legs, trunk, or groin


• softening of the skin

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Texacort side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Texacort resources

• Texacort Side Effects (in more detail)
• Texacort Use in Pregnancy & Breastfeeding
• Texacort Drug Interactions
• Texacort Support Group
• 0 Reviews for Texacort - Add your own review/rating

• Texacort Concise Consumer Information (Cerner Multum)


• Texacort Prescribing Information (FDA)


• Anucort-HC cream, ointment, suppository Concise Consumer Information (Cerner Multum)


• Anusol-HC Cream MedFacts Consumer Leaflet (Wolters Kluwer)


• Carmol HC Prescribing Information (FDA)


• Carmol HC Concise Consumer Information (Cerner Multum)


• Carmol HC MedFacts Consumer Leaflet (Wolters Kluwer)


• Cortizone-10 Cream MedFacts Consumer Leaflet (Wolters Kluwer)


• Hydrocortisone Acetate Monograph (AHFS DI)


• Hydrocortisone with Aloe Cream MedFacts Consumer Leaflet (Wolters Kluwer)


• Hytone Prescribing Information (FDA)


• Instacort Gel MedFacts Consumer Leaflet (Wolters Kluwer)


• Locoid Cream MedFacts Consumer Leaflet (Wolters Kluwer)


• Locoid Lipocream Prescribing Information (FDA)


• Locoid Lotion Prescribing Information (FDA)


• Nutracort Concise Consumer Information (Cerner Multum)


• Nutracort Lotion MedFacts Consumer Leaflet (Wolters Kluwer)


• Pandel Prescribing Information (FDA)


• Pediaderm HC Lotion MedFacts Consumer Leaflet (Wolters Kluwer)


• ProctoCream-HC Cream MedFacts Consumer Leaflet (Wolters Kluwer)


• Proctocort Prescribing Information (FDA)


• U-cort Prescribing Information (FDA)


• Westcort Prescribing Information (FDA)

Compare Texacort with other medications

• Anal Itching
• Aphthous Stomatitis, Recurrent
• Atopic Dermatitis
• Dermatitis
• Eczema
• Gingivitis
• Proctitis
• Pruritus
• Psoriasis
• Seborrheic Dermatitis
• Skin Rash
• Ulcerative Colitis, Active

Cocarboxylase

In some countries, this medicine may only be approved for veterinary use.

Scheme

Rec.INN

CAS registry number (Chemical Abstracts Service)

0000154-87-0

Chemical Formula

C12-H19-Cl-N4-O7-P2-S

Molecular Weight

460

Therapeutic Category

Vitamin B₁

Chemical Name

Thiazolium, 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-4-methyl-5-(4,6,6-trihydroxy-3,5-dioxa-4,6-diphosphahex-1-yl)-, chloride, P,P'-dioxide

Foreign Names

• Cocarboxylasum (Latin)
• Co-carboxylase (German)
• Cocarboxylase (French)
• Cocarboxilasa (Spanish)

Generic Names

• Cocarbossilasi (OS: DCIT)
• Cocarboxylase (OS: BAN, JAN, DCF)
• Co-Carboxylase (IS)
• Diphosphothiamine (IS)
• DPT (IS)
• Pyrophosphoric ester of thiamine (IS: WHO)
• Pyruvodehydrase (IS)
• Thiamine pyrophosphate (IS: IUPAC)

Brand Names

• Carzilasa
  Manuell, Mexico



• Puroffit
  Isei, Japan



• X-2
  Investigaciones Filosoficas, Mexico



• Bicarbossilasi (veterinary use)
  Teknofarma, Italy



• Cocarboxylasa
  Jelfa, Latvia



• Cocarboxylase Hydrochloric for Injection
  Biopharm, Georgia



• Cocarboxylase Jelfa
  Jelfa, Georgia; Jelfa, Hungary; Jelfa, Slovakia



• Cocarboxylasum
  Jelfa, Poland; Polpharma, Poland

International Drug Name Search

Glossary

BAN	British Approved Name
DCF	Dénomination Commune Française
DCIT	Denominazione Comune Italiana
IUPAC	International Union of Pure and Applied Chemistry
IS	Inofficial Synonym
JAN	Japanese Accepted Name
OS	Official Synonym
Rec.INN	Recommended International Nonproprietary Name (World Health Organization)
WHO	World Health Organization

Click for further information on drug naming conventions and International Nonproprietary Names.

calcitonin injection

Generic Name: calcitonin injection (kal si TOE nin)

Brand Names: Miacalcin

What is calcitonin injection?

Calcitonin is a man-made form of a hormone that occurs naturally in the thyroid gland.

Calcitonin injection is used to treat Paget's disease of bone, postmenopausal osteoporosis, or high levels of calcium in the blood (hypercalcemia).

Calcitonin may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about calcitonin injection?

Do not use this medication if you are allergic to salmon calcitonin. To make sure you are not allergic to this medication, your doctor may perform an allergy skin test before your first dose of calcitonin injection.

Calcitonin injection is not a cure for Paget's disease and you may have a relapse, especially if your body forms antibodies and you become immune to calcitonin. Talk with your doctor at any time if you think the medication is not working as well as it did before.

To be sure this medication is helping your condition, your blood will need to be tested on a regular basis. Your urine may also need to be tested. Do not miss any scheduled appointments.

Calcitonin injection can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

It is important to use calcitonin injection regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

What should I discuss with my health care provider before using calcitonin injection?

Do not use this medication if you are allergic to salmon calcitonin.

Before using calcitonin injection, tell your doctor if you are allergic to any food or drugs. You may need a dose adjustment or special tests to safely use this medication.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether calcitonin passes into breast milk or if it could harm a nursing baby. Calcitonin may slow breast milk production. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I use calcitonin injection?

Use this medication exactly as it was prescribed for you. Do not use the medication in larger amounts, or use it for longer than recommended by your doctor. Follow the instructions on your prescription label.

To make sure you are not allergic to this medication, your doctor may perform an allergy skin test before your first dose of calcitonin injection.

This medication is given as an injection under the skin. Your doctor, nurse, or other healthcare provider will give you this injection. You may be shown how to inject your medicine at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles and syringes.

Use each disposable needle only one time. Throw away used needles in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.

Calcitonin injection is not a cure for Paget's disease and you may have a relapse, especially if your body forms antibodies and you become immune to calcitonin. Talk with your doctor at any time if you think the medication is not working as well as it did before.

To be sure this medication is helping your condition, your blood will need to be tested on a regular basis. Your urine may also need to be tested. Do not miss any scheduled visits to your doctor.

It is important to use calcitonin injection regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

Store this medication in the refrigerator and do not allow it to freeze.

What happens if I miss a dose?

Use the medication as soon as you remember the missed dose. If it is almost time for your next dose, skip the missed dose and use the medicine at your next regularly scheduled time. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include nausea or vomiting.

What should I avoid while using calcitonin injection?

Follow your doctor's instructions about any restrictions on food, beverages, or activity while you are using calcitonin injection.

Calcitonin injection can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Calcitonin injection side effects

You may have increased bone pain during the first few months of treatment with calcitonin injection. This is not a sign that the medication isn't working properly.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:

• 
  

  feeling light-headed, fainting; or

  
  


• 
  

  muscle stiffness.

  
  

Less serious side effects may include:

• 
  

  warmth, redness, itching, or tingly feeling under your skin;

  
  


• 
  

  nausea, loss of appetite, stomach pain;

  
  


• 
  

  vomiting;

  
  


• 
  

  skin rash or itching;

  
  


• 
  

  increased urination, especially at night;

  
  


• 
  

  eye pain;

  
  


• 
  

  swelling in your feet; or

  
  


• 
  

  swelling or irritation of the skin where an injection was given.

  
  

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

Calcitonin injection Dosing Information

Usual Adult Dose for Paget's Disease:

50 to 100 intl units given subcutaneously or intramuscularly once a day. The dosage may be reduced to 50 to 100 intl units subcutaneously or intramuscularly three times a week when improvement (clinical or biochemical) occurs. Calcitonin is usually not given for more than 6 months unless there are neurological symptoms or extensive lytic lesions in the weight-bearing bones. Biochemical remissions of the illness generally last for under six months. If retreatment is necessary, the same initial and maintenance dosage schedules generally are repeated. Human calcitonin is an orphan drug that may be used in patients that develop resistance or an allergic reaction to calcitionin-salmon.

-or-

200 to 400 intl units by intranasal administration once a day may also be used with a slight loss in efficacy (400 intl units nasal dose compared to 100 intl units intramuscular dose) but a decrease in systemic side effects. Studies have demonstrated that intranasal preparations reduced bone turnover by 30% to 40%, compared to the 50% seen with subcutaneous or intramuscular preparations.

Usual Adult Dose for Hypercalcemia:

4 intl units/kg (rounded to the next higher 5 intl units) subcutaneously or intramuscularly every 12 hours. The maximum dosage should not exceed 545 intl units per dose. If a response to the 4 intl units/kg dose is not observed in 1 to 2 days, 8 intl units/kg (rounded to the next higher 5 intl units) may be given subcutaneously or intramuscularly every 12 hours. The dosing frequency may be increased to every 6 hours, if needed. The maximum dosage should not exceed 1090 intl units per dose. Therapy is generally 5 days or fewer. A 2 mg/dl reduction in plasma calcium level is usually noted and maintained for 2 to 4 days. Thereafter, the effect diminishes.

Usual Adult Dose for Osteoporosis:

100 intl units given every other day or 50 intl units given once a day either subcutaneously or intramuscularly. Injectable doses may be increased to 200 or 400 intl units once per day, as required.

-or-

200 intl units may be given intranasally once a day, alternating nostrils daily.

Therapy is generally long-term, lasting months or years.

Usual Adult Dose for Osteogenesis Imperfecta Tarda:

50 intl units given subcutaneously three times a week. Dosages may be increased to 100 intl units depending on tolerance of side effects and efficacy of the 50 intl units dose therapy.

Usual Pediatric Dose for Osteogenesis Imperfecta Tarda:

Not a FDA approved indication:
Osteogenesis imperfecta
Children over 6 months of age: 2 international units/kg IM or SQ 3 times/week.

What other drugs will affect calcitonin injection?

There may be other drugs that can affect calcitonin injection. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

More calcitonin injection resources

• Calcitonin injection Side Effects (in more detail)
• Calcitonin injection Dosage
• Calcitonin injection Use in Pregnancy & Breastfeeding
• Calcitonin injection Drug Interactions
• Calcitonin injection Support Group
• 2 Reviews for Calcitonin - Add your own review/rating

Compare calcitonin injection with other medications

• Hypercalcemia
• Osteogenesis Imperfecta
• Osteoporosis
• Paget's Disease

Where can I get more information?

• Your pharmacist can provide more information about calcitonin injection.

See also: calcitonin side effects (in more detail)

prasugrel

PRA-soo-grel

Oral route(Tablet)

Prasugrel can cause significant, sometimes fatal, bleeding in patients with active pathological bleeding or a propensity to bleed, a history of transient ischemic attack or stroke, a body weight of less than 60 kg, or concomitant use of medications that increase the risk of bleeding (eg, warfarin, heparin, fibrinolytics, chronic use of NSAIDs). Prasugrel is not recommended in patients 75 years of age and older, except for high-risk situations (diabetes, history of prior myocardial infarction). Do not start prasugrel in patients likely to undergo urgent CABG and discontinue at least 7 days prior to any surgery. If possible, manage bleeding without discontinuing prasugrel, as discontinuation in the first few weeks after acute coronary syndrome may increase risk for subsequent cardiovascular events .

Commonly used brand name(s)

In the U.S.

• Effient

Available Dosage Forms:

• Tablet

Therapeutic Class: Platelet Aggregation Inhibitor

Pharmacologic Class: ADP-Induced Aggregation Inhibitor

Uses For prasugrel

Prasugrel is used to prevent strokes, heart attacks, or other serious problems with your heart or blood vessels. It is given to patients before they have a heart procedure called percutaneous coronary intervention (PCI).

A heart attack or stroke may occur when a blood vessel in the heart or brain is blocked by a blood clot. Prasugrel reduces the chance that a harmful blood clot will form by preventing certain cells in the blood from clumping or sticking together. Prasugrel may also increase the chance for serious bleeding in some people.

prasugrel is available only with your doctor's prescription.

Before Using prasugrel

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For prasugrel, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to prasugrel or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of prasugrel in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of prasugrel in the elderly. Because of prasugrel's toxicity, use in elderly patients 75 years of age and older is not recommended.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	B	Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking prasugrel, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using prasugrel with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Alteplase, Recombinant


• Cilostazol


• Citalopram


• Dabigatran Etexilate


• Desirudin


• Escitalopram


• Fluoxetine


• Fluvoxamine


• Nefazodone


• Paroxetine


• Rivaroxaban


• Sertraline


• Warfarin

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of prasugrel. Make sure you tell your doctor if you have any other medical problems, especially:

• Bleeding (eg, head, stomach, or bowel bleeding), active or


• Stroke, history of or


• Transient ischemic attack (TIA) or "mini-stroke", history of—Should not be used in patients with these conditions.

• Hypersensitivity reaction to clopidogrel (Plavix®) or ticlopidine (Ticlid®), history of or


• Liver disease, severe or


• Low body weight (less than 60 kilograms or 132 pounds) or


• Stomach or bowel bleeding, recurrent or


• Stomach ulcer or


• Surgery or other procedures (eg, heart bypass surgery, coronary angiography, PCI), recent or


• Trauma, recent—Use with caution. May increase risks for more serious side effects.

Proper Use of prasugrel

Take prasugrel exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.

Do not stop taking prasugrel without checking with your doctor first. To do so may increase your risk for clots.

prasugrel should come with a medication guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.

You may take prasugrel with or without food.

Dosing

The dose of prasugrel will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of prasugrel. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage form (tablets):
  
  • For prevention of heart attacks or strokes:
    
    • Adults weighing 60 kilograms (kg) and above—At first, 60 milligrams (mg) taken as a single loading dose, and then 10 mg once a day. You may take prasugrel with aspirin (75 to 325 mg) once a day.
    
    
    • Adults weighing less than 60 kilograms (kg)—At first, 60 milligrams (mg) taken as a single loading dose, and then 5 mg once a day.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  

Missed Dose

If you miss a dose of prasugrel, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using prasugrel

It is very important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it. Blood tests may be needed to check for unwanted effects.

Tell all of your medical doctors, dentists, and nurses that you are taking prasugrel. Prasugrel may increase the risk of serious bleeding during an operation or some dental procedures. Treatment may have to be stopped about 7 days before the operation or dental procedure.

Check with your doctor right away if you have the following symptoms: change in mental status, dark or bloody urine, difficulty with speaking, fever, pale color of the skin, pinpoint red spots on the skin, seizures, weakness, yellow eyes or skin. These may be symptoms of a serious condition called thrombotic thrombocytopenic purpura (TTP).

prasugrel may cause serious allergic reactions, including angioedema. Angioedema can be life-threatening and requires immediate medical attention. Stop using prasugrel and tell your doctor right away if you have chest pain; a rash; itching; swelling of the face, lips, tongue, or throat; or trouble with swallowing or breathing while you are using the medicine.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

prasugrel Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

• Blurred vision


• dizziness


• headache


• nervousness


• pounding in the ears


• slow or fast heartbeat

Less common

• Black, tarry stools


• bloating or swelling of the face, arms, hands, lower legs, or feet


• chest pain or discomfort


• chills


• cough


• difficult or labored breathing


• fainting


• fever


• irregular heartbeat


• lightheadedness, dizziness, or fainting


• painful or difficult urination


• rapid weight gain


• shortness of breath


• sore throat


• sores, ulcers, or white spots on the lips or in the mouth


• swollen glands


• tightness in the chest


• tingling of the hands or feet


• unusual bleeding or bruising


• unusual tiredness or weakness


• unusual weight gain or loss


• wheezing

Incidence not known

• Change in mental status


• dark or bloody urine


• difficulty with speaking


• fever


• pale color of the skin


• pinpoint red spots on the skin


• seizures


• weakness


• yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

• Back pain


• diarrhea


• nausea


• pain in the arms or legs


• rash

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: prasugrel side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More prasugrel resources

• Prasugrel Side Effects (in more detail)
• Prasugrel Dosage
• Prasugrel Use in Pregnancy & Breastfeeding
• Prasugrel Drug Interactions
• Prasugrel Support Group
• 5 Reviews for Prasugrel - Add your own review/rating

• Prasugrel Professional Patient Advice (Wolters Kluwer)


• Prasugrel Monograph (AHFS DI)


• Prasugrel MedFacts Consumer Leaflet (Wolters Kluwer)


• Effient Prescribing Information (FDA)


• Effient Consumer Overview

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Cromoglicic Acid disodium salt (a derivative of Cromoglicic Acid) is reported as an ingredient of Cromogen in the following countries:

• Poland

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Elliotts B Solution

Dosage Form: injection, solution
ELLIOTTS B® SOLUTION (buffered intrathecal electrolyte/dextrose injection)

Rx Only

Elliotts B Solution Description

Elliotts B® Solution is a sterile, nonpyrogenic, isotonic solution containing no bacteriostatic preservatives. Elliotts B Solution is a diluent for intrathecal administration of methotrexate sodium and cytarabine.

Each 10 mL of Elliotts B Solution contains:

Sodium Chloride, USP	73 mg
Sodium Bicarbonate, USP	19 mg
Dextrose, USP	8 mg
Magnesium Sulfate • 7H2O, USP	3 mg
Potassium Chloride, USP	3 mg
Calcium Chloride • 2H2O, USP	2 mg
Sodium Phosphate, dibasic • 7H2O, USP	2 mg
Water for Injection, USP	qs 10 mL

Concentration of Electrolytes:

Sodium	149 mEq/liter	Bicarbonate	22.6 mEq/liter
Potassium	4.0 mEq/liter	Chloride	132 mEq/liter
Calcium	2.7 mEq/liter	Sulfate	2.4 mEq/liter
Magnesium	2.4 mEq/liter	Phosphate	1.5 mEq/liter

The formulae and molecular weights of the ingredients are:

INGREDIENT	MOLECULAR FORMULA	MOLECULAR WEIGHT
Sodium Chloride	NaCl	58.44
Sodium Bicarbonate	NaHCO3	84.01
Dextrose	C6H12O6	180.16
Magnesium Sulfate • 7H2O	Mg2SO4 • 7H2O	246.48
Potassium Chloride	KCl	74.55
Calcium Chloride • 2H2O	CaCl2 • 2H2O	147.01
Sodium Phosphate, dibasic • 7H2O	Na2HPO4 • 7H2O	268.07

The pH of Elliotts B Solution is 6.0-7.5, and the osmolarity is 288 mOsmol per liter (calculated).

Elliotts B Solution - Clinical Pharmacology

Elliotts B Solution provides a buffered salt solution for use as a diluent for the intrathecal administration of methotrexate sodium and cytarabine. It has been demonstrated that Elliotts B Solution is comparable to cere­brospinal fluid in pH, electrolyte composition, glucose content, and osmolarity:

Comparison of Electrolyte Composition, pH and Nonelectrolytic Constituents of Elliotts B Solution and CSF

Solution	Na+ mEq/L	K+ mEq/L	Ca++ mEq/L	Mg++ mEq/L	HCO3- mEq/L	Cl- mEq/L	pH	Phosphorus mg/dL	Glucose mg/dL
Cerebrospinal Fluid	117-137	2.3-4.6	2.2	2.2	22.9	113-127	7.31	1.2-2.1	45-80
Elliotts B Solution	149	4.0	2.7	2.4	22.6	132	6.0-7.5	2.3	80

The approximate buffer capacity of Elliotts B Solution is 1.1 X 10-2 equivalents when the challenge solution is 0.01 N HCl and 7.8 X 10-3 equivalents when the challenge solution is 0.01 N NaOH.1

Compatibility studies with methotrexate sodium and cytarabine indicate these drugs are physically compati­ble with Elliotts B Solution.

Indications and Usage for Elliotts B Solution

Elliotts B Solution is indicated as a diluent for the intrathecal administration of methotrexate sodium and cytarabine for the prevention or treatment of meningeal leukemia or lymphocytic lymphoma.

Contraindications

None known.

Warnings

Intrathecal administration of drugs such as methotrexate sodium and cytarabine should be performed by per­sonnel skilled in the technique of lumbar puncture under the supervision of a physician who is experienced in the use of cancer chemotherapeutic agents. The labeling for methotrexate sodium and cytarabine should be consulted.

Precautions

General

Particular attention should be taken to assure the maintenance of sterile technique throughout the procedure. (See DOSAGE AND ADMINISTRATION.)

Carcinogenesis, Mutagenesis, Impairment of Fertility

No standard mutagenicity or carcinogenicity studies have been conducted with Elliotts B Solution.

Usage in Pregnancy

Pregnancy Category C

All components of Elliotts B Solution are normal body constituents. Animal reproduction studies have not been conducted with Elliotts B Solution.

Adverse Reactions

Adverse reactions may occur with any given intrathecal injection due to the chemotherapy or the technique of intrathecal administration.  (See product labeling for methotrexate sodium and cytarabine.)

Preservative-free methotrexate sodium and cytarabine should be used to minimize adverse reactions due to preservatives.

If an adverse reaction does occur, discontinue the administration, evaluate the patient, institute appropriate therapeutic countermeasures and, if possible, save the remainder of the unused solution(s) for examination.

Overdosage

Elliotts B Solution is a diluent. In the event of a drug, fluid or solute overload following administration, evalu­ate the patient's condition, and institute appropriate corrective treatment. (See product labeling for methotrexate sodium and cytarabine.)

Elliotts B Solution Dosage and Administration

See product labeling for methotrexate sodium and cytarabine.

Elliotts B Solution is intended for intrathecal administration only.  Elliotts B Solution does not contain antibac­terial preservatives and introduction of contaminated solutions into the cerebrospinal fluid may have extremely serious consequences. Therefore, administration of intrathecal solutions should be accomplished as soon as possible after preparation.

A sterile filter-needle should be used to withdraw the contents of the ampule.

Intrathecal drug products should be inspected visually for particulate matter and discoloration prior to admin­istration.

Preparation and Administration Precautions

Elliotts B Solution is a diluent for the cytotoxic anticancer agents, methotrexate sodium and cytarabine. Care should be exercised in the handling and preparation of infusion solutions with these products. (See product labeling for methotrexate sodium and cytarabine.)

How is Elliotts B Solution Supplied

NDC	SIZE
67871-007-10	10 mL ampule

Elliotts B Solution is available in single-use clear glass ampules, packaged 10 ampules per box.


Store at controlled room temperature, 20º-25ºC (68º-77ºF) [See USP].


Preservative Free.  Discard unused portion.  Use only if solution is clear and ampule is intact.


Manufactured by:  Ben Venue Laboratories, Inc.

                            Bedford, Ohio  44146


Distributed by:    QOL Medical LLC

                         Kirkland, WA  98033

                         1-866-528-4750

                         www.elliottsbsolution.com

REFERENCES:

1. Cradock JC, et al. Evaluation of some pharmaceutical aspects of intrathecal methotrexate sodium, cytara­bine and hydrocortisone sodium succinate.  American Journal of Hospital Pharmacy (1978); 35:402.

Rev. 09/06

Part No. 210

PACKAGING

Ampule labeling:

Box labeling:

ELLIOTTS B  buffered intrathecal electrolyte/dextrose  injection, solution

Product Information Product Type HUMAN PRESCRIPTION DRUG NDC Product Code (Source) 67871-007 Route of Administration INTRATHECAL DEA Schedule

Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength sodium chloride (sodium cation and chloride ion) sodium chloride 73 mg  in 10 mL sodium bicarbonate (sodium cation and bicarbonate ion) sodium bicarbonate 19 mg  in 10 mL dextrose (dextrose) dextrose 8 mg  in 10 mL magnesium sulfate, unspecified (magnesium cation and sulfate ion) magnesium sulfate, unspecified 3 mg  in 10 mL potassium chloride (potassium cation and chloride ion) potassium chloride 3 mg  in 10 mL calcium chloride (calcium cation and chloride ion) calcium chloride 2 mg  in 10 mL sodium phosphate (sodium cation and phosphate ion) sodium phosphate 2 mg  in 10 mL

Inactive Ingredients Ingredient Name Strength Water 10 mL  in 10 mL

Product Characteristics Color      Score      Shape Size Flavor Imprint Code Contains

Packaging # NDC Package Description Multilevel Packaging 1 67871-007-10 10 AMPULE In 1 BOX contains a AMPULE (67871-007-01) 1 67871-007-01 10 mL In 1 AMPULE This package is contained within the BOX (67871-007-10)

Marketing Information
Marketing Category	Application Number or Monograph Citation	Marketing Start Date	Marketing End Date
NDA	NDA020577	09/01/2006

Labeler - QOL Medical LLC (140026258)

Revised: 03/2011QOL Medical LLC